Epistemological problems in subcellular biology: observations, mathematical models and computer simulations

Authors

  • Andrzej Bielecki

DOI:

https://doi.org/10.15633/ss.2482

Keywords:

experiment, observation, theory, model, numerical simulations, subcellular biology

Abstract

Relations between theory and empirical knowledge belong to basic problems
in philosophy of science and have been undergone detailed philosophical reflection,
including epistemological aspects. During last several dozen years,
due to development of computer technology, numerical simulations became
a common tool in natural sciences. Their epistemological aspects, however,
have not worked out yet. A specific role of computer simulations manifests
in subcellular biology, where possibilities of performing experiments and observations
are limited. Computer simulation is complementary to observation
and experiment and comes into complex relations with them. It allows us to
come to a conclusion if experiment or observations are impossible to perform.
In particular, simulations allow researchers to estimate the parameters that
cannot be measured.

References

Bielecki A., Gierdziewicz M., Kalita P., Szostek K., Construction of a 3D Geometric

Model of a Presynaptic Bouton for Use in Modeling of Neurotransmitter

Flow, „Lecture Notes in Computer Science” 9972 (2016), s. 377–386.

Bielecki A., Kalita P., Lewandowski M., Siwek B., Numerical Simulation for

a Neurotransmitter Transport Model in the Axon Terminal of a Presynaptic

Neuron, „Biological Cybernetics” 102 (2010), s. 489–502.

Bielecki A., Kalita P., Lewandowski M., Skomorowski M., Compartment Model

of Neuropeptide Synaptic Transport with Impulse Control, „Biological

Cybernetics” 99 (2008), s. 443–458.

Bielecki A., Kalita P., Model of Neurotransmitter Fast Transport in Axon

Terminal of a Presynaptic Neuron, „Journal of Mathematical Biology”

(2008), s. 559–576.

Bielecki A., Mierzalne i niemierzalne, „Świat Nauki” 245 (2012), s. 82–83.

Brooks B. R., Bruccoleri R. E., Olafson B. D., States D. J., Swaminathan S.,

Karplus M., CHARMM: A Program for Macromolecular Energy, Minimization

and Dynamics Calculations, „Journal of Computational Chemistry”

(1982), s. 187–217.

Carnap R., Logiczna struktura świata, tłum. P. Kawalec, Warszawa 2011.

Dzik J., Dzieje życia na Ziemi, Warszawa 2003.

Futuyma D. J., Ewolucja, tłum. J. Radwan, Warszawa 2008.

Heller M., Filozofia nauki. Wprowadzenie, Kraków 2011.

Heller M., Matematyczna a filozoficzna teoria miary, „Zagadnienia Filozoficzne

w Nauce” 51 (2012), s. 152–154.

Hempel C. G., Filozofia nauk przyrodniczych, tłum. B. Stanosz, Warszawa

Hillman H., Two Problems with Cell Biology and What Should Be Done about

Them, „Biologist” 57 (2010) iss. 1, s. 40–44.

Knodel M., Geiger R., Ge L., Bucher D., Grillo A., Wittum G., Schuster C.,

Queisser G., Synaptic Bouton Properties Are Tuned to Best Fit the Prevailing

Firing Pattern, „Frontiers in Computational Neuroscience” 8 (2014)

Epistemologiczne problemy w biologii subkomórkowej… 23

art. 101, https://www.frontiersin.org/articles/10.3389/fncom.2014.00101/

full (27.11.2017).

Lakatos I., Pisma z filozofii nauk empirycznych, tłum. W. Sady, Warszawa

Lenartowicz P., Elementy filozofii zjawiska biologicznego, Kraków 1984.

Olejnik R., Matematyczna teoria miary a metodologiczne analizy procedur pomiarowych,

Tarnów 2011.

Popper K. R., Droga do wiedzy. Domysły i refutacje, tłum. S. Amsterdamski,

Warszawa 1999.

Popper K. R., Logika odkrycia naukowego, tłum. U. Niklas, Warszawa 2002.

Popper K. R., Wiedza obiektywna. Ewolucyjna teoria epistemologiczna, tłum.

A. Chmielewski, Warszawa 2002.

Solomon E. P., Berg L. R., Martin D. W., Biologia, tłum. A. Borowska i in.,

Warszawa 2014.

Wilhelm B. G., Mandad S., Truckenbrodt S., Krohnert K., Schafer C., Rammner

B., Seong J. K., Gala A. C., Krauss M., Haucke V., Urlaub H., Rizzoli S. O.,

Composition of Isolated Synaptic Boutons Reveals the Amounts of Vesicle

Trafficking Proteins, „Science” 344 (2014), s. 1023–1028.

Życiński J., Elementy filozofii nauki, Kraków 2015.

Downloads

Published

2018-07-31

Issue

Section

Artykuły